Neurogenic pain originates in unmyelinated (bare) nerve fibers and in free nerve endings. They can influence the Central Nervous System through the depolarization and activation of nociceptors that are usually inactive. This can happen in two ways: with the application of mechanical strength intense enough to press, deform or damage the tissues which have nociceptors or with the presence of enough concentrations of irritating chemical substances (bradykinin, histamine, among others) on the fluid that goes through the tissues containing the nociceptive receptors.
These substances are released in traumatized, inflamed, necrosed, metabolically abnormal and ischemic tissues. The nociceptor system has full distribution in the lumbosacral region, and postulates that there are no nerve endings in the intervertebral disc. Lumbar pains (lower back pain) can be influenced by many factors, such as: pain of mechanical origin, pain originated from incorrect postures, pain caused by disturbs.